In the game, each player brings a set of dice to the table; these form his team, from which only he can purchase dice. In addition, each player brings two basic action cards, which are placed in the center of the table; both players can purchase them.

During a turn, a player draws and rolls a number of his dice, purchases additional dice, and fields character dice to attack the other player. A player wins once the opposing player has been reduced to zero life.

Yu-Gi-Oh! Dice Masters is one of several planned Dice Masters games, all of which can be intermixed (or played alone).